lncRNA与癌症

综述：循环MicroRNA：黑色素瘤预后和治疗的生物标志物

By xiaoai

2025-03-29

这篇综述系统阐述了循环miRNA在黑色素瘤诊断、预后预测和治疗中的重要作用。作者指出miRNA通过调控MAPK通路、免疫检查点（PD-1/CTLA-4）等关键靶点参与肿瘤微环境调控，其独特的稳定性和组织特异性使其成为理想的液体活检标志物。尽管面临标准化挑战，MEL38等miRNA特征谱已展现出90%以上的诊断准确性，而miR-155等免疫调节miRNA与治疗响应密切相关。文章特别强调miRNA疗法（如MRX34）与靶向治疗/免疫治疗的协同潜力，为个体化治疗提供了新思路。 Molecular Cancer 27.7
黑色素瘤的挑战与机遇

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